Neurodevelopmental disorders: Attention Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD) and Sensory Processing Disorder (SPD)
A Single-Arm Pivotal Trial to Assess the Efficacy of Akl-T01, a Novel Digital Intervention for Attention, in Adults Diagnosed With ADHD: Presented at the Seventieth Annual Meeting of the American Academy of Child & Adolescent Psychiatry (AACAP), October 23-28, 2023
Open label EEG study in children with ADHD: Published in PloS ONE on December 31, 2021
Gallen, C. L., Anguera, J. A., Gerdes, M. R., Simon, A. J., Cañadas, E., & Marco, E. J. (2021). Enhancing neural markers of attention in children with ADHD using a digital therapeutic. PloS one, 16(12), e0261981
Open label study in children with ADHD, both on and off medications: Published in npj Digital Medicine on March 26, 2021
Kollins, S.H., Childress, A, Heusser, AC and Lutz, J. (2021). Effectiveness of a digital therapeutic as adjunct to treatment with medication in pediatric ADHD. npj Digit. Med. 4, 58. https://doi.org/10.1038/s41746-021-00429-0
Pilot Study and three-years follow up study in SPD and co-occurring ADHD in children: Published in PLoS ONE on April 17, 2017 and PLoS ONE on February 4, 2021
Anguera JA, Brandes-Aitken AN, Antovich AD, Rolle CE, Desai SS, and Marco EJ. A pilot study to determine the feasibility of enhancing cognitive abilities in children with sensory processing dysfunction. PLoS One. 2017;12(4):1-19. doi:10.1371/journal.pone.
Jurigova, B. G., Gerdes, M. R., Anguera, J. A., & Marco, E. J. (2021). Sustained benefits of cognitive training in children with inattention, three-year follow-up. PLoS one, 16(2), e0246449.
Randomized controlled trial in ADHD in children: Published in Lancet Digital Health on February 24, 2020
Kollins, SH, DeLoss, DJ, Canadas, E, et al. A novel digital intervention for actively reducing severity of paediatric ADHD (STARS-ADHD): a randomized controlled trial Lancet Digital Health 2020; 2(4): PE168-E178 doi: https://doi.org/10.1016/S2589-7500(20)30017-0
Open-label study in ADHD in children, with and without stimulant medication: Presented at the Sixty-seventh Annual Meeting of the American Academy of Child & Adolescent Psychiatry (AACAP), October 12-24, 2020
Multi-study analysis on moving objective measures of attention into normative ranges in ADHD with AKL-T01: Presented at Sixty-seventh Annual Meeting of the American Academy of Child & Adolescent Psychiatry (AACAP), October 12-24, 2020
Pilot study in ASD and co-occurring ADHD in children: Published in Journal of Autism and Developmental Disorders on December 19, 2018
Yerys BE, Bertollo JR, Kenworthy L, et al. Brief Report: Pilot Study of a Novel Interactive Digital Treatment to Improve Cognitive Control in Children with Autism Spectrum Disorder and Co-occurring ADHD Symptoms. J Autism Dev Disord. 2019;49(4):1727-1737. doi:10.1007/s10803-018-3856-7
Proof of concept study in ADHD in children: Published in PLoS ONE on January 11, 2018
Davis, NO, Bower, J, and Kollins, SH. Proof-of-concept study of an at-home engaging, digital intervention for pediatric ADHD. PLoS One, 2018, 13(1): e0189749. https://doi.org/10.1371/journal.pone.0189748
Other Publications
Randomized controlled trial in Major Depressive Disorder in adults: Published in American Journal of Psychiatry on April 12, 2022
Keefe, R. S., Cañadas, E., Farlow, D., & Etkin, A. (2022). Digital Intervention for Cognitive Deficits in Major Depression: A Randomized Controlled Trial to Assess Efficacy and Safety in Adults. American Journal of Psychiatry, appi-ajp.
Mechanistic study in Major Depressive Disorder in adults: Published in Translational Psychiatry on May 4th, 2021
Gunning, F.M., Anguera, J.A., Victoria, L.W. & Arean, P. (2021). A digital intervention targeting cognitive control network dysfunction in middle age and older adults with major depression. Transl Psychiatry 11, 269. https://doi.org/10.1038/s41398-021-01386-8
Feasibility study on cognitive monitoring in adult with Multiple Sclerosis: Published in Journal of Medical Internet Research on September 15, 2020
Hsu, W. Y., Rowles, W., Anguera, J., Zhao, C., Anderson, A., Alexander, A., ... & Bove, R. (2021). Application of an Adaptive, Digital, Game-Based Approach for Cognitive Assessment in Multiple Sclerosis: Observational Study. Journal of medical Internet research, 23(1), e24356
Randomized controlled trial in Multiple Sclerosis in adults: Published in Multiple Sclerosis Journal on June 25, 2020.
Bove, R., Rowles, W., Zhao, C., Anderson, A., Friedman, S., Langdon, D., ... & Anguera, J. A. (2020). A novel in-home digital treatment to improve processing speed in people with multiple sclerosis: A pilot study. Multiple Sclerosis Journal, 1352458520930371.
Feasibility study on cognitive monitoring in children with learning disabilities: Published in Journal of Autism and developmental disorders on January 17, 2019
Flynn, R.M., Colón-Acosta, N., Zhou, J. et al. A Game-Based Repeated Assessment for Cognitive Monitoring: Initial Usability and Adherence Study in a Summer Camp Setting. J Autism Dev Disord 49, 2003–2014 (2019). http://doi.org/10.1007/s1083-019-03881-w
Pilot study in Multiple Sclerosis in adults: Published in Neurology and Therapy on November 30, 2018
Bove, R. M., Rush, G., Zhao, C., Rowles, W., Garcha, P., Morrissey, J., ... & Gazzaley, A. (2019). A Videogame-Based Digital Therapeutic to Improve Processing Speed in People with Multiple Sclerosis: A Feasibility Study. Neurology and therapy, 8(1), 135-145.
Pilot study in Major Depressive Disorder in adults: Published in Depression and Anxiety on January 3, 2017
Anguera, J.A., Gunning, F.M., & Areán, P.A. (2017). Improving late life depression and cognitive control through the use of therapeutic video game technology: A proof-of-concept randomized trial. Depression and anxiety, 34(6), 508-517.
Two feasibility studies on remote intervention in Major Depressive Disorder in adults: Published in BMJ Innovation on February 4, 2016 and Journal of Medical Internet Research on December 20, 2016
Arean, P. A., Hallgren, K. A., Jordan, J. T., Gazzaley, A., Atkins, D. C., Heagerty, P. J., & Anguera, J. A. (2016). The Use and Effectiveness of Mobile Apps for Depression: Results From a Fully Remote Clinical Trial. Journal of medical Internet research, 18(12), e330. https://doi.org/10.2196/jmir.6482
Anguera JA, Jordan JT, Castaneda D, et al Conducting a fully mobile and randomised clinical trial for depression: access, engagement and expense BMJ Innovations 2016;2:14-21.
Pilot study on cognitive assessments in children with a genetic variation implicated in ADHD and ASD: Published in Translation Psychiatry on September 20, 2016
Anguera, J., Brandes-Aitken, A., Rolle, C. et al. Characterizing cognitive control abilities in children with 16p11.2 deletion using adaptive ‘video game’ technology: a pilot study. Transl Psychiatry 6, e893 (2016). https://doi.org/10.1038/tp.2016.178
Proof of concept study on cognitive control in older adults: Published in Nature on September 4, 2013
Anguera, J., Boccanfuso, J., Rintoul, J. et al. Video game training enhances cognitive control in older adults. Nature 501, 97–101 (2013). https://doi.org/10.1038/nature12486